Stopping suddenly may cause serious side effects. Olanzapine is sometimes used together with other antipsychotic medications or antidepressants. Use all medications as directed and read all medication guides you receive. Do not change your dose or dosing schedule without your doctor's advice. Medication may be only part of a complete program of treatment that also includes counseling and other psychological support programs. Follow your doctor's instructions. Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose.
Do not take two doses at one time. Overdose symptoms may include drowsiness, agitation, aggression, slurred speech, confusion, increased heart rate, jerky or uncontrolled muscle movements, trouble breathing, or fainting. Avoid driving or hazardous activity until you know how this medicine will affect you. Dizziness or drowsiness can cause falls, accidents, or severe injuries. Avoid becoming overheated or dehydrated.
Drink plenty of fluids, especially in hot weather and during exercise. It is easier to become dangerously overheated and dehydrated while you are taking olanzapine. Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Seek medical treatment if you have a serious drug reaction that can affect many parts of your body. Symptoms may include: skin rash, fever, swollen glands, muscle aches, severe weakness, unusual bruising, or yellowing of your skin or eyes. High doses or long-term use of olanzapine can cause a serious movement disorder that may not be reversible.
The longer you use olanzapine, the more likely you are to develop this disorder, especially if you are a woman or an older adult. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. Taking olanzapine with other drugs that make you sleepy or slow your breathing can cause dangerous or life-threatening side effects.
Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures. Other drugs may affect olanzapine, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Every effort has been made to ensure that the information provided by Cerner Multum, Inc. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise.
Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient.
You and your doctor should talk about how long you need to take olanzapine before you start your treatment. If you stop the olanzapine, you will go back for checks to see that your old symptoms do not come back. For psychosis or schizophrenia , if you have had one episode of illness, then it is best for you to keep taking olanzapine for at least two years to reduce the chances of becoming ill again.
If you have had more than one episode of illness, then a period of at least five years is recommended. If you are taking olanzapine to treat bipolar mania or bipolar depression, then you will need to discuss long-term medicines for your bipolar disorder with your doctor.
This is to help stop the illness coming back. For bipolar disorder, it is important to remain on medicines in the long term because every time you become ill, there is more chance of you becoming ill again. Olanzapine can be used as a long-term medicine, but there are other choices and lithium is still thought to be the best long-term medicine for bipolar disorder.
You should discuss your options with your doctor. For schizoaffective disorder, it is probably best to keep taking the olanzapine for several years to reduce the chances of the illness coming back. We know less about schizoaffective disorder, but it has some similarities to bipolar disorder and some similarities to schizophrenia.
Depression is usually treated with an antidepressant medicine, and olanzapine is sometimes added to an antidepressant for more severe depression. For people with severe depression, it is best to continue the antidepressant medicine for at least two years to stop the illness from coming back.
The doctor is likely to recommend continuing olanzapine for the same length of time. You will get the best effect from olanzapine if you take it every day at the dose prescribed by your doctor. Make sure that you know your dose. If it is not written on the label, check with your pharmacist or doctor. It is usually recommended to take olanzapine at bedtime because it can cause sleepiness as a side effect. However, it is important to choose a time of day to take it that you can easily remember, which could be bedtime, a mealtime, or when you brush your teeth.
For the plain-coated tablets, swallow them whole with a drink of water - if you chew them, they taste bitter. Put orodispersible tablets melts on your tongue and let them dissolve there. You can also dissolve these in a glass of water, orange juice, apple juice or milk and then drink it all down. A doctor or nurse can give you an injection in your bottom that provides a long-lasting dose of olanzapine, lasting for two or four weeks.
You may need to take tablets alongside the injection, especially while the dose builds up. Every time you have the injection, you will be asked to wait at the centre for at least three hours so that they can check that the injection is not giving you too much olanzapine in one go. It is slowly working in your body all the time between injections. If you forget to take it by bedtime, just start again on the next day.
Do not take a double dose. If it is less than 12 hours before your next dose of olanzapine, then do not take the missed dose because taking the doses too close together could cause more side effects. If you miss your appointment for your injection, contact your doctor or nurse straight away to make another appointment. If you forget to take your tablets for a while, or you miss an injection, you may start getting your old symptoms back.
You should talk to your doctor if this happens. Once you start taking an antipsychotic, the brain adjusts to having a new level of dopamine around.
If you stop taking the antipsychotic all at once, the balance starts to change again. You could get your old symptoms back. Stopping this medicine quickly, or reducing the dose too much at once, may cause your old symptoms to come back, or cause you some withdrawal effects.
You may get your old symptoms back if you stop olanzapine for a while. You can also get withdrawal effects, including:. It is better to agree stopping with a doctor who will reduce your dose gradually. This is likely to take a few weeks. You will probably go for checks with your doctor after you stop olanzapine to check that you still feel better. If you have taken more olanzapine than the dosage recommended by the doctor who prescribed it to you, you must get medical help immediately — even if you do not feel any different.
Olanzapine can sometimes cause serious side effects. Tell your doctor immediately if you experience unusual movements mainly of the face or tongue. Go to hospital immediately if you think you may have developed a blood clot symptoms are usually swelling, pain and redness in the leg - a clot may travel through blood vessels to the lungs causing chest pain and difficulty breathing.
Also go to hospital and tell the doctor you are taking olanzapine if you develop a combination of fever, faster breathing, sweating, muscle stiffness or drowsiness. Stopping olanzapine suddenly can cause withdrawal effects and stopping it too early could cause your illness to come back. See your doctor if you want to stop taking olanzapine because it is better to come off it gradually. You might feel sleepy or dizzy in the first few days after taking olanzapine.
Do not drive a car, ride a bike or operate machines until you see how this affects you. If you are pregnant, or thinking of becoming pregnant, please read the pregnancy section under the 'Side Effects' tab because olanzapine may affect the developing baby. Take your medicine with you to show to the doctors. Tell them how much you have taken. Get a friend to go with you, if you can, just in case you feel ill on the way. Go to a doctor or hospital straight away if you get any of the following symptoms while taking olanzapine:.
You need to talk to your doctor or pharmacist before starting treatment with olanzapine if any of the following apply to you:. You should have your weight, blood sugar, blood fats, blood pressure and pulse measured regularly during early treatment, then at least every six months to a year after that, depending on your age. You should also have your blood sugar tested when you start, after one month, and then every four to six months after that.
The doctor might also check your heart with an electrocardiogram ECG and check your blood pressure. They might also check your height and development. If you have periods, they may also check whether they are regular. Please do not be worried by the side effects listed on this page. Discuss this with your healthcare provider. Do not double your next dose or take more than what is prescribed. If you miss a dose of olanzapine long-acting injection, see your healthcare provider to receive your dose as soon as possible.
Avoid drinking alcohol or using illegal drugs while you are taking olanzapine. They may decrease the benefits e. If an overdose occurs, call your doctor or You may need urgent medical care. You may also contact the poison control center at Low blood pressure, drowsiness, extrapyramidal symptoms, restlessness, dizziness, headache, fatigue, insomnia, increased prolactin, weight gain, increased appetite, dry mouth, indigestion, constipation, liver function test abnormalities, weakness, accidental injury.
Olanzapine may increase the blood levels of a hormone called prolactin. Side effects of increased prolactin levels include females losing their period, production of breast milk and males losing their sex drive or possibly experiencing erectile problems.
Long term months or years of elevated prolactin can lead to osteoporosis, or increased risk of bone fractures. Some people may develop muscle related side effects while taking olanzapine.
Symptoms of EPS include restlessness, tremor, and stiffness. TD symptoms include slow or jerky movements that one cannot control, often starting in the mouth with tongue rolling or chewing movements.
Temperature regulation: Impaired core body temperature regulation may occur; caution with strenuous exercise, heat exposure, and dehydration. Second generation antipsychotics SGAs increase the risk of weight gain, high blood sugar, and high cholesterol. This is also known as metabolic syndrome. Your healthcare provider may ask you for a blood sample to check your cholesterol, blood sugar, and hemoglobin A1c a measure of blood sugar over time while you take this medication.
All antipsychotics have been associated with the risk of sudden cardiac death due to an arrhythmia irregular heartbeat. To minimize this risk, antipsychotic medications should be used in the smallest effective dose when the benefits outweigh the risks.
Your doctor may order an EKG to monitor for irregular heartbeat. Symptoms include confusion, fever, extreme muscle stiffness, and sweating. If any of these symptoms occur, contact your healthcare provider immediately. All antipsychotics can cause sedation, dizziness, or orthostatic hypotension a drop in blood pressure when standing up from sitting or lying down. These side effects may lead to falls which could cause bone fractures or other injuries.
This risk is higher for people with conditions or other medications that could worsen these effects. If falls or any of these symptoms occur, contact your healthcare provider. Multiorgan hypersensitivity reactions drug reaction with eosinophilia and systemic symptoms [DRESS] : Potentially serious, sometimes fatal, multiorgan hypersensitivity reactions have been reported. Tardive dyskinesia TD is a side effect that develops with prolonged use of antipsychotics.
If you develop symptoms of TD, such as grimacing, sucking, and smacking of lips, or other movements that you cannot control, contact your healthcare provider immediately.
Call or visit Get someone else to drive you or call for an ambulance. Take the olanzapine packet or leaflet inside it, plus any remaining medicine with you. Take the olanzapine packet or leaflet inside it plus any remaining medicine with you. Like all medicines, olanzapine can cause side effects, although not everyone gets them. These common side effects may affect up to 1 in 10 people. Tell your doctor if these side effects bother you or do not go away:.
Call or go to In rare cases, it's possible to have a serious allergic reaction anaphylaxis to olanzapine. These are not all the side effects of olanzapine. For a full list see the leaflet inside your medicines packet.
Olanzapine can be taken during pregnancy and is not thought to be harmful to your baby. Your mental health and wellbeing are important. If you become pregnant while taking olanzapine, speak to your doctor. You will be reviewed in a specialised antenatal clinic and you can discuss your medicine with the doctors in the clinic. If your doctor or health visitor says your baby is healthy, you can take olanzapine while breastfeeding.
Olanzapine passes into breast milk in very small amounts and has been linked with side effects in very few breastfed babies. Many people have used it while breastfeeding without any problems. It's important to keep taking olanzapine to keep you well. Breastfeeding will also benefit both you and your baby. If you notice that your baby is not feeding as well as usual, seems unusually sleepy or seems irritable, or if you have any other concerns about your baby, talk to your health visitor, midwife, pharmacist or doctor as soon as possible.
Cannabidiol also known as CBD might affect how olanzapine works. Do not take cannabidiol while you are taking olanzapine. There might be a problem taking some other herbal remedies and supplements with olanzapine, especially ones that make you feel sleepy or dizzy. Tell your doctor or pharmacist if you're taking any other medicines, including herbal medicines, vitamins or supplements.
Olanzapine belongs to a group of medicines called antipsychotics. It does not cure your condition, but it can help to improve the symptoms of mental health conditions. Olanzapine works by affecting naturally occurring chemical messengers in your brain neurotransmitters , like dopamine. If you have too much dopamine it can make you see or hear things that are not there hallucinations , or think things that others do not delusions. Dopamine is also involved in muscle movements, so too much of it can affect your muscles.
Olanzapine also works on other neurotransmitters such as serotonin and noradrenaline. Olanzapine rebalances these to improve your mood and behaviour. Taking olanzapine will not change your personality and it is not addictive. Olanzapine, like many medicines, does not work straight away. It can take a few weeks to get the dose right for you. It may take several days or even weeks for some of your symptoms to get better.
Carry on taking your medicine for as long as your doctor tells you to, even if you feel better. Do not stop taking your medicine without talking to your doctor first. When you first start taking olanzapine, it may make you feel more relaxed and calm. Within 2 to 3 weeks, your other symptoms may start to improve. Yes, many people take olanzapine for a long time, including for many months or years, without any problems.
Olanzapine can increase the amount of sugar in your blood and this can sometimes lead to diabetes. Keeping to a healthy weight can help to prevent this. You will usually have a blood test before you start olanzapine treatment to see how much sugar you have in your blood.
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